Welcome back to Daktari Cases.
This case comes complete with a soundtrack courtesy of Merle Haggard, as well as an existential reference from Hamlet Act 3 Scene 1; so the recommended gameplan, start Merle out and have him playing in the background while you read the story.
The story of Charles goes like this: he is a young man of 25 years, a local guy from Bomet who grew up in the burgeoning Kenyan middle class. He has lived the good life for our area: always had food on the table and school fees keep him on the track to success: education is the way out of poverty here, and Kenyans take it very seriously.
Then three years ago he started to get a cough. He shrugged it off for a few weeks, until people started to notice. Then he went to the clinic and told them his story: he'd had a chronic cough, and was an otherwise healthy young man. In our part of the world, that means he has pulmonary tuberculosis (TB), plus or minus HIV. His chest x-ray showed the abnormalities on the left upper lobe, and a sputum culture was sent. Sensitivity for sputum culture in our setting is @ 50%, so most clinical decisions are made based on clinical evaluation. For Charles, the clinical evaluation said, "TB" and he was started on TB treatment.
He felt better over a couple of weeks, but kept taking his treatment for the full prescribed 6-month course. 4 drugs x 3 times per day.
Nothing happened for a few months after he finished his initial treatment. He returned to work and led a normal successful life for another quarter of a year. Then his cough came back...same symptoms as before, and he returned to the clinic. This time the exam and the x-ray showed the abnormality on the right side of the chest. This was deeply concerning to the clinical staff, at the back of our minds there is always the question of evolving drug resistance in tuberculosis, and when we see these HIV-negative patients returning to clinic with a relapse or recurrence, there is a fear that they are in the 2-4% of patients with drug-resistant TB in our area. Another sputum sample is taken and is negative.
So, Charles gets second-line treatment for the new set of symptoms and radiographic findings. This time he gets 4 drugs 3 times per day, and a daily shot of a drug called Streptomycin, a very painful and inconvenient everyday experience for 9 months.
Once again, he gets better for a few months, and then has a recurrence of his symptoms. He gets treated again with another course of intramuscular Streptomycin.
On the fourth recurrence of his symtoms, I get involved in his care. He is admitted to the Tenwek Medicine Teaching Service, and we go back through his story. He has had 4 treatment courses for sputum-negative TB that seems to move around from one side of his chest to the other. Maybe there is something else going on here? Some of the dangers of working in Africa amidst so much TB is that you start to call everything TB.
And for this case, I wasn't convinced. I spoke with my surgeon colleagues, and asked them to do a biopsy of his lung. At Tenwek we can do a procedure called a video-assisted thoracoscopic surgery (VATS), illustrated here. This gave us a piece of tissue to examine: is this TB or something else?And it turns out this case was of something else: Bronchiolitis Obliterans Organizing Pneumonia (more handily named BOOP). It's an inflammatory lung disease that responds to a short course of steroids, something as simple as a week of prednisone like you get for poison ivy.
Charles doesn't have TB, nor does he need the stigma and fear associated with it.
That takes us back to the existential question that we on the medicine service ask ourselves daily: TB or not TB; that is the question.













